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Conditional CD8+ T Cell Escape during Acute Simian Immunodeficiency Virus Infection

Shelby O'Connor, Ericka Becker, Jason Weinfurter, Emily Chin, Melisa Budde, Emma Gostick, Michael Correll, Michael Gleicher, Austin Hughes, David Price, Thomas Friedrich, David O'Connor
Journal of Virology, Volume 86, Number 1, page 605--609 — jan 2012
CD8+ T cell responses rapidly select viral variants during acute human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) infection. We used pyrosequencing to examine variation within three SIV-derived epitopes (Gag386-394GW9, Nef103-111RM9, and Rev59-68SP10) targeted by immunodominant CD8+ T cell responses in acutely infected Mauritian cynomolgus macaques. In animals recognizing all three epitopes, variation within Rev59-68SP10 was associated with delayed accumulation of variants in Gag386-394GW9 but had no effect on variation within Nef103-111RM9. This demonstrates that the entire T cell repertoire, rather than a single T cell population, influences the timing of immune escape, thereby providing the first example of conditional CD8+ T cell escape in HIV/SIV infection.

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BibTex references

  author       = "O'Connor, Shelby and Becker, Ericka and Weinfurter, Jason and Chin, Emily and Budde, Melisa and Gostick, Emma and Correll, Michael and Gleicher, Michael and Hughes, Austin and Price, David and Friedrich, Thomas and O'Connor, David",
  title        = "Conditional CD8+ T Cell Escape during Acute Simian Immunodeficiency Virus Infection",
  journal      = "Journal of Virology",
  number       = "1",
  volume       = "86",
  pages        = "605--609",
  month        = "jan",
  year         = "2012",
  ee           = "http://jvi.asm.org/content/86/1/605.long",
  doi          = "10.1128/JVI.05511-11",
  projecturl   = "http://graphics.cs.wisc.edu/Vis/LayerCake/",
  url          = "http://graphics.cs.wisc.edu/Papers/2012/OBWCBGCGHPFO12"

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